Post-mortem study of the association between cardiac iron and fibrosis in transfusion dependent anaemia.

ABSTRACT:

Background

Heart failure related to cardiac siderosis remains a major cause of death in transfusion dependent anaemias. Replacement fibrosis has been reported as causative of heart failure in siderotic cardiomyopathy in historical reports, but these findings do not accord with the reversible nature of siderotic heart failure achievable with intensive iron chelation.

Methods

Ten whole human hearts (9 beta-thalassemia major, 1 sideroblastic anaemia) were examined for iron loading and fibrosis (replacement and interstitial). Five had died from heart failure, 4 had cardiac transplantation for heart failure, and 1 had no heart failure (death from a stroke). Heart samples iron content was measured using atomic emission spectroscopy. Interstitial fibrosis was quantified by computer

SUBMITTER: Kirk P 

PROVIDER: S-EPMC5367003 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature