MicroRNAs miR-7 and miR-340 predict response to neoadjuvant chemotherapy in breast cancer.

ABSTRACT:

Purpose

miRNAs have been linked to chemosensitivity of breast cancer cells in vitro. In patients, however, there is no clinically validated method for predicting chemotherapy response. The aim of this study was to assess whether (I) a specific pattern of miRNA expression in pretherapeutic biopsies can predict response to neoadjuvant chemotherapy, and (II) differential miRNA expression in residual tumor after completion of chemotherapy allows further prognostic stratification of non-responding patients.

Methods

Sixty-four patients with newly diagnosed large (≥3 cm) or locally advanced primary breast cancers who underwent neoadjuvant anthracycline/taxane-based chemotherapy were included. Relative expression of 10 miRNAs likely to be associated with chemotherapy response (miR-7

SUBMITTER: Raychaudhuri M 

PROVIDER: S-EPMC5367042 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature