Antiviral Drug-Resistant Influenza B Viruses Carrying H134N Substitution in Neuraminidase, Laos, February 2016.
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ABSTRACT:
SUBMITTER: Baranovich T
PROVIDER: S-EPMC5367415 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
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Antiviral Drug-Resistant Influenza B Viruses Carrying H134N Substitution in Neuraminidase, Laos, February 2016.
Baranovich Tatiana T Vongphrachanh Phengta P Ketmayoon Pakapak P Sisouk Thongchanh T Chomlasack Khampheng K Khanthamaly Viengphone V Nguyen Ha Thuy HT Mishin Vasiliy P VP Marjuki Henju H Barnes John R JR Garten Rebecca J RJ Stevens James J Wentworth David E DE Gubareva Larisa V LV
Emerging infectious diseases 20170401 4
In February 2016, three influenza B/Victoria/2/87 lineage viruses exhibiting 4- to 158-fold reduced inhibition by neuraminidase inhibitors were detected in Laos. These viruses had an H134N substitution in the neuraminidase and replicated efficiently in vitro and in ferrets. Current antiviral drugs may be ineffective in controlling infections caused by viruses harboring this mutation. ...[more]
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