Is there a relation between novelty seeking, striatal dopamine release and frontal cortical thickness?

ABSTRACT:

Background

Novelty-seeking (NS) and impulsive personality traits have been proposed to reflect an interplay between fronto-cortical and limbic systems, including the limbic striatum (LS). Although neuroimaging studies have provided some evidence for this, most are comprised of small samples and many report surprisingly large effects given the challenges of trying to relate a snapshot of brain function or structure to an entity as complex as personality. The current work tested a priori hypotheses about associations between striatal dopamine (DA) release, cortical thickness (CT), and NS in a large sample of healthy adults.

Methods

Fifty-two healthy adults (45M/7F; age: 23.8±4.93) underwent two positron emission tomography scans with [11C]raclopride (specific for striatal DA D

SUBMITTER: Jaworska N 

PROVIDER: S-EPMC5367687 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature