Breast cancer in patients with Li-Fraumeni syndrome - a case-series study and review of literature.

ABSTRACT:

Background

Li-Fraumeni Syndrome (LFS) is a rare disease with autosomal dominant inheritance linked to germline mutations of tumor suppressor gene TP53. These patients are predisposed to malignancies such as sarcoma, breast cancer, leukemia, and other malignancies. Breast cancer, the most common malignancy in adult patients with LFS, has an early-onset presentation and is usually treated as per the guidelines for the general population due to the limited literature about breast cancer in LFS. We aimed to describe our institutional experience treating patients with breast cancer and LFS to contribute to literature about this entity.

Design

Retrospective single-institution case-series study. We searched for cases with LFS and breast cancer from 01/01/2000 to 12/31/2015 w

SUBMITTER: Nandikolla AG 

PROVIDER: S-EPMC5367777 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature