Modelling T cell proliferation: Dynamics heterogeneity depending on cell differentiation, age, and genetic background.

ABSTRACT: Cell proliferation is the common characteristic of all biological systems. The immune system insures the maintenance of body integrity on the basis of a continuous production of diversified T lymphocytes in the thymus. This involves processes of proliferation, differentiation, selection, death and migration of lymphocytes to peripheral tissues, where proliferation also occurs upon antigen recognition. Quantification of cell proliferation dynamics requires specific experimental methods and mathematical modelling. Here, we assess the impact of genetics and aging on the immune system by investigating the dynamics of proliferation of T lymphocytes across their differentiation through thymus and spleen in mice. Our investigation is based on single-cell multicolour flow cytometry analysis reveal

SUBMITTER: Vibert J 

PROVIDER: S-EPMC5367836 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature