Towards improved butanol production through targeted genetic modification of Clostridium pasteurianum.

ABSTRACT: Declining fossil fuel reserves, coupled with environmental concerns over their continued extraction and exploitation have led to strenuous efforts to identify renewable routes to energy and fuels. One attractive option is to convert glycerol, a by-product of the biodiesel industry, into n-butanol, an industrially important chemical and potential liquid transportation fuel, using Clostridium pasteurianum. Under certain growth conditions this Clostridium species has been shown to predominantly produce n-butanol, together with ethanol and 1,3-propanediol, when grown on glycerol. Further increases in the yields of n-butanol produced by C. pasteurianum could be accomplished through rational metabolic engineering of the strain. Accordingly, in the current report we have developed and exemplified

SUBMITTER: Schwarz KM 

PROVIDER: S-EPMC5367854 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature