The genetics of isoflurane-induced developmental neurotoxicity.

ABSTRACT:

Introduction

Neurotoxicity induced by early developmental exposure to volatile anesthetics is a characteristic of organisms across a wide range of species, extending from the nematode C. elegans to mammals. Prevention of anesthetic-induced neurotoxicity (AIN) will rely upon an understanding of its underlying mechanisms. However, no forward genetic screens have been undertaken to identify the critical pathways affected in AIN. By characterizing such pathways, we may identify mechanisms to eliminate isoflurane induced AIN in mammals.

Methods

Chemotaxis in adult C. elegans after larval exposure to isoflurane was used to measure AIN. We initially compared changes in chemotaxis indices between classical mutants known to affect nervous system development adding mutants in response

SUBMITTER: Na HS 

PROVIDER: S-EPMC5367966 | biostudies-literature | 2017 Mar - Apr

REPOSITORIES: biostudies-literature