A comparison of methods for estimating the incidence of human immunodeficiency virus infection in repeat blood donors.

ABSTRACT:

Background

The incidence of human immunodeficiency virus (HIV) in repeat blood donors has been estimated using seven methods. Although incidence is always calculated as cases per person-time, approaches to selecting cases and calculating person-time vary. Incidence estimates have not been compared among methods.

Study design and methods

The seven methods were compared in a simulation study. Because three methods used information from donations made before an estimation interval, 8 years of donation and infection history were simulated, and Years 7 and 8 were treated as the estimation interval for all methods. An exponential random variate was assigned to each donor to simulate the time to infection. Infection risk was constant over 8 years in one scenario but increased at va

SUBMITTER: Brambilla DJ 

PROVIDER: S-EPMC5368013 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature