Signal Detection of Imipenem Compared to Other Drugs from Korea Adverse Event Reporting System Database.

ABSTRACT:

Purpose

To detect signals of adverse drug events after imipenem treatment using the Korea Institute of Drug Safety & Risk Management-Korea adverse event reporting system database (KIDS-KD).

Materials and methods

We performed data mining using KIDS-KD, which was constructed using spontaneously reported adverse event (AE) reports between December 1988 and June 2014. We detected signals calculated the proportional reporting ratio, reporting odds ratio, and information component of imipenem. We defined a signal as any AE that satisfied all three indices. The signals were compared with drug labels of nine countries.

Results

There were 807582 spontaneous AEs reports in the KIDS-KD. Among those, the number of antibiotics related AEs was 192510; 3382 reports were associated w

SUBMITTER: Park K 

PROVIDER: S-EPMC5368142 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature