Gender-Specific Associations between CHGB Genetic Variants and Schizophrenia in a Korean Population.

ABSTRACT:

Purpose

Schizophrenia is a devastating mental disorder and is known to be affected by genetic factors. The chromogranin B (CHGB), a member of the chromogranin gene family, has been proposed as a candidate gene associated with the risk of schizophrenia. The secretory pathway for peptide hormones and neuropeptides in the brain is regulated by chromogranin proteins. The aim of this study was to investigate the potential associations between genetic variants of CHGB and schizophrenia susceptibility.

Materials and methods

In the current study, 15 single nucleotide polymorphisms of CHGB were genotyped in 310 schizophrenia patients and 604 healthy controls.

Results

Statistical analysis revealed that two genetic variants (non-synonymous rs910122; rs2821 in 3'-untranslated reg

SUBMITTER: Shin JG 

PROVIDER: S-EPMC5368149 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature