NKCC1 up-regulation contributes to early post-traumatic seizures and increased post-traumatic seizure susceptibility.

ABSTRACT: Traumatic brain injury (TBI) is not only a leading cause for morbidity and mortality in young adults (Bruns and Hauser, Epilepsia 44(Suppl 10):210, 2003), but also a leading cause of seizures. Understanding the seizure-inducing mechanisms of TBI is of the utmost importance, because these seizures are often resistant to traditional first- and second-line anti-seizure treatments. The early post-traumatic seizures, in turn, are a contributing factor to ongoing neuropathology, and it is critically important to control these seizures. Many of the available anti-seizure drugs target gamma-aminobutyric acid (GABA_A) receptors. The inhibitory activity of GABA_A receptor activation depends on low intracellular Cl^-, which is achieved by the opposing regulation of Na

SUBMITTER: Wang F 

PROVIDER: S-EPMC5368191 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature