Association between IL-4 and IL-4R Polymorphisms and Periodontitis: A Meta-Analysis.

ABSTRACT: Background. Previous studies have revealed that gene polymorphisms of inflammatory factors may influence the development or progression of periodontitis, a main cause of tooth loss in adults; however, due to limitations of individual studies, inconsistent findings were reported. Objective. To meta-analytically investigate the relationship between periodontitis and the Interleukin-4 (IL-4) and Interleukin-4 receptor (IL-4R) gene polymorphisms. Methods. Databases were searched for relevant case-control studies. After study selection based on the predefined selection criteria, methodological quality assessment and data extraction were conducted independently by two reviewers, before subsequent statistical analyses. Results. 37 studies involving 4,385 patients and 5

SUBMITTER: Jia XW 

PROVIDER: S-EPMC5368398 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature