Effects of control interventions on Clostridium difficile infection in England: an observational study.

ABSTRACT:

Background

The control of Clostridium difficile infections is an international clinical challenge. The incidence of C difficile in England declined by roughly 80% after 2006, following the implementation of national control policies; we tested two hypotheses to investigate their role in this decline. First, if C difficile infection declines in England were driven by reductions in use of particular antibiotics, then incidence of C difficile infections caused by resistant isolates should decline faster than that caused by susceptible isolates across multiple genotypes. Second, if C difficile infection declines were driven by improvements in hospital infection control, then transmitted (secondary) cases should decline regardless of susceptibility.

Methods

Regional (Oxfordshire

SUBMITTER: Dingle KE 

PROVIDER: S-EPMC5368411 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature