Association of the rs10757274 SNP with coronary artery disease in a small group of a Pakistani population.

ABSTRACT:

Objective

The present study aimed to investigate the association between the rs10757274 SNP (present on locus 9p21 in the gene for CDKN2B-AS1) and coronary artery disease (CAD) in a local population of Pakistan.

Methods

It was a case-control study. An allele-specific PCR-based strategy was used for the identification of genotypes. A total of 350 samples were used for the investigation, out of which 220 samples were CAD patients and 130 samples were normal healthy individuals. Effects of parameters, like family history of CAD, smoking, presence of diabetes, and hypertension, in changing the chances of CAD were studied. Odds ratio was estimated with 95% confidence interval.

Results

A strong association was observed between CAD and factors, like smoking (OR: 1.666; 95% C

SUBMITTER: Nawaz SK 

PROVIDER: S-EPMC5368478 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature