Neural Crest Cells Contribute an Astrocyte-like Glial Population to the Spleen.

ABSTRACT: Neural crest cells (NCC) are multi-potent cells of ectodermal origin that colonize diverse organs, including the gastrointestinal tract to form the enteric nervous system (ENS) and hematopoietic organs (bone marrow, thymus) where they participate in lymphocyte trafficking. Recent studies have implicated the spleen as an anatomic site for integration of inflammatory signals from the intestine with efferent neural inputs. We have previously observed alterations in splenic lymphocyte subsets in animals with defective migration of NCC that model Hirschsprung's disease, leading us to hypothesize that there may be a direct cellular contribution of NCC to the spleen. Here, we demonstrate that NCC colonize the spleen during embryogenesis and persist into adulthood. Splenic NCC display markers indi

SUBMITTER: Barlow-Anacker AJ 

PROVIDER: S-EPMC5368681 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature