A Frameshift Mutation in KIT is Associated with  White Spotting in the Arabian Camel.

ABSTRACT: While the typical Arabian camel is characterized by a single colored coat, there are rare populations with white spotting patterns. White spotting coat patterns are found in virtually all domesticated species, but are rare in wild species. Theories suggest that white spotting is linked to the domestication process, and is occasionally associated with health disorders. Though mutations have been found in a diverse array of species, fewer than 30 genes have been associated with spotting patterns, thus providing a key set of candidate genes for the Arabian camel. We obtained 26 spotted camels and 24 solid controls for candidate gene analysis. One spotted and eight solid camels were whole genome sequenced as part of a separate project. The spotted camel was heterozygous for a frameshift deleti

SUBMITTER: Holl H 

PROVIDER: S-EPMC5368706 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature