Epigenetic signatures of gestational diabetes mellitus on cord blood methylation.

ABSTRACT:

Background

Intrauterine exposure to gestational diabetes mellitus (GDM) confers a lifelong increased risk for metabolic and other complex disorders to the offspring. GDM-induced epigenetic modifications modulating gene regulation and persisting into later life are generally assumed to mediate these elevated disease susceptibilities. To identify candidate genes for fetal programming, we compared genome-wide methylation patterns of fetal cord bloods (FCBs) from GDM and control pregnancies.

Methods and results

Using Illumina's 450K methylation arrays and following correction for multiple testing, 65 CpG sites (52 associated with genes) displayed significant methylation differences between GDM and control samples. Four candidate genes, ATP5A1, MFAP4, PRKCH,

SUBMITTER: Haertle L 

PROVIDER: S-EPMC5368916 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature