Targeted sequencing may facilitate differential diagnostics of pulmonary tumours: a case series.

ABSTRACT:

Background

Histopathological diagnosis is important for prognostication and choice of treatment in patients with cancer in the lung. Metastases to the lungs are common and need to be distinguished from primary lung cancer. Furthermore, cases with synchronous or metachronous primary lung cancers (although infrequent) are often handled differently than cases with lung cancer with intrapulmonary metastasis or relapse, respectively. In some cases, morphology and immunohistochemical staining is not sufficient for certain diagnosis.

Methods

The present study included six cases where molecular genetic analysis in form of pyrosequencing or targeted next-generation sequencing was of value for certain diagnosis of selected tumours in the lung.

Results

Two of the included cases

SUBMITTER: Ericson-Lindquist K 

PROVIDER: S-EPMC5368924 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature