Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury.

ABSTRACT: Oxidative stress reflects an imbalance between reactive oxygen species (ROS) and antioxidants, which has been reported as an early unifying event in the development and progression of various diseases and as a direct and mechanistic indicator of treatment response. However, highly reactive and short-lived nature of ROS and antioxidant limited conventional detection agents, which are influenced by many interfering factors. Here, we present a two-photon sensing platform for in vivo dual imaging of oxidative stress at the single cell-level resolution. This sensing platform consists of three probes, which combine the turn-on fluorescent transition-metal complex with different specific responsive groups for glutathione (GSH), hydrogen peroxide (H₂O₂) and hypochlorous acid

SUBMITTER: Wang H 

PROVIDER: S-EPMC5368978 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature