STAT3 and NF-κB are Simultaneously Suppressed in Dendritic Cells in Lung Cancer.

ABSTRACT: Tumour-induced dendritic cell (DC) dysfunction plays an important role in cancer immune escape. However, the underlying mechanisms are not yet fully understood, reflecting the lack of appropriate experimental models both in vivo and in vitro. In the present study, an in vitro study model for tumour-induced DC dysfunction was established by culturing DCs with pooled sera from multiple non-small cell lung cancer (NSCLC) patients. The results demonstrated that tumour-induced human monocyte-derived DCs exhibited systematic functional deficiencies. Transcriptomics analysis revealed that the expression of major functional cluster genes, including the MHC class II family, cytokines, chemokines, and co-stimulatory molecules, was significantly altered in tumour-induced DCs compared to that in contr

SUBMITTER: Li R 

PROVIDER: S-EPMC5368983 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature