Pharmacokinetic and Pharmacodynamic Responses to Clopidogrel: Evidences and Perspectives.

ABSTRACT: Clopidogrel has significantly reduced the incidence of recurrent atherothrombotic events in patients with acute coronary syndrome (ACS) and in those undergoing percutaneous coronary intervention (PCI). However, recurrence events still remain, which may be partly due to inadequate platelet inhibition by standard clopidogrel therapy. Genetic polymorphisms involved in clopidogrel's absorption, metabolism, and the P2Y12 receptor may interfere with its antiplatelet activity. Recent evidence indicated that epigenetic modification may also affect clopidogrel response. In addition, non-genetic factors such as demographics, disease complications, and drug-drug interactions can impair the antiplatelet effect of clopidogrel. The identification of factors contributing to the variation in clopidogrel r

SUBMITTER: Zhang YJ 

PROVIDER: S-EPMC5369137 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature