Mild, Redox-Neutral Alkylation of Imines Enabled by an Organic Photocatalyst.

ABSTRACT: An operationally simple, mild, redox-neutral method for the photoredox alkylation of imines is reported. Utilizing an inexpensive organic photoredox catalyst, alkyl radicals are readily generated from the single-electron oxidation of ammonium alkyl bis(catecholato)silicates and are subsequently engaged in a C-C bond-forming reaction with imines. The process is highly selective, metal-free, and does not require a large excess of the alkylating reagent or the use of acidic additives.

SUBMITTER: Patel NR 

PROVIDER: S-EPMC5369175 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature