A phase II study of preoperative chemoradiation with tegafur-uracil plus leucovorin for locally advanced rectal cancer with pharmacogenetic analysis.

ABSTRACT:

Background

This study aimed to evaluate the efficacy of a high dose of oral tegafur-uracil (400 mg/m²) plus leucovorin with preoperative chemoradiation of locally advanced rectal cancer and to explore the impact of polymorphisms of cytochrome P 2A6 (CYP2A6), uridine monophosphate synthetase (UMPS), and ATP-binding cassette B1 (ABCB1) on clinical outcome.

Methods

Patients with cT3 or cT4 rectal cancer were enrolled and were given tegafur-uracil 400 mg/m²/day and leucovorin 90 mg/m²/day for 7 days a week during preoperative chemoradiation (50.4 Gy/28 fractions) in this phase II trial. Primary endpoint was pathologic complete response rate, and the secondary endpoint was to explore the association between clinical outcomes and genetic polymorphi

SUBMITTER: Kim SY 

PROVIDER: S-EPMC5369180 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature