First report of the Phe1534Cys kdr mutation in natural populations of Aedes albopictus from Brazil.

ABSTRACT:

Background

Knockdown resistance (kdr), caused by alterations in the voltage-gated sodium channel (Na_V), is one of the mechanisms responsible for pyrethroid (PY) resistance. In the Asian tiger mosquito, Aedes albopictus, at least four different mutations were described in the IIIS6 Na_V segment in populations from Asia, North America and Europe. In contrast, in Aedes aegypti at least 12 non-synonymous mutations have been reported at nine different codons, mostly in the IIS6 and IIIS6 Na_V segments. The Phe1534Cys kdr mutation in the IIIS6 Na_V segment is the most prevalent in populations of Ae. aegypti worldwide, also found in Ae. albopictus from Singapore. Herein, we investigated the DNA diversity corresponding to the IIS6 and IIIS6 Na_V

SUBMITTER: Aguirre-Obando OA 

PROVIDER: S-EPMC5369189 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature