Weight loss independent changes in adipose tissue macrophage and T cell populations after sleeve gastrectomy in mice.

ABSTRACT:

Objective

In addition to adipocytes, adipose tissue contains large numbers of immune cells. A wide range of evidence links the activity of these cells to regulation of adipocyte and systemic metabolic function. Bariatric surgery improves several aspects of metabolic derangements and at least some of these effects occur in a weight-loss independent manner. We sought to investigate the impact of vertical sleeve gastrectomy (VSG) on adipose immune cell frequencies.

Methods

We analyzed the frequencies of immune cells within distinct adipose tissue depots in obese mice that had VSG or sham surgery with a portion of the latter group pair-fed such that their body mass was matched to the VSG animals.

Results

We demonstrate that VSG induced a shift in the epididymal adipose ti

SUBMITTER: Frikke-Schmidt H 

PROVIDER: S-EPMC5369283 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature