Enhancement of the physicochemical properties of [Pt(dien)(nucleobase)]²⁺ for HIVNCp7 targeting.

ABSTRACT: Physicochemical properties of coordination compounds can be exploited for molecular recognition of biomolecules. The inherent π-π stacking properties of [Pt(chelate)(N-donor)]²⁺ ([PtN₄]) complexes were modulated by systematic variation of the chelate (diethylenetriamine and substituted derivatives) and N-donor (nucleobase or nucleoside) in the formally substitution-inert PtN₄ coordination sphere. Approaches to target the HIV nucleocapsid protein HIVNCp7 are summarized building on (i) assessment of stacking interactions with simple tryptophan or tryptophan derivatives to (ii) the tryptophan-containing C-terminal zinc finger and (iii) to the full two-zinc finger peptide and its interactions with RNA and DNA. The xanthosine nucleoside was identified as having

SUBMITTER: Tsotsoros SD 

PROVIDER: S-EPMC5369524 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature