Effect of Omega-3 Fatty Acids, Lutein/Zeaxanthin, or Other Nutrient Supplementation on Cognitive Function: The AREDS2 Randomized Clinical Trial.

ABSTRACT:

Importance

Observational data have suggested that high dietary intake of saturated fat and low intake of vegetables may be associated with increased risk of Alzheimer disease.

Objective

To test the effects of oral supplementation with nutrients on cognitive function.

Design, setting, and participants

In a double-masked randomized clinical trial (the Age-Related Eye Disease Study 2 [AREDS2]), retinal specialists in 82 US academic and community medical centers enrolled and observed participants who were at risk for developing late age-related macular degeneration (AMD) from October 2006 to December 2012. In addition to annual eye examinations, several validated cognitive function tests were administered via telephone by trained personnel at baseline and every 2 years du

SUBMITTER: Chew EY 

PROVIDER: S-EPMC5369607 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature