Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study.

ABSTRACT:

Background

Alzheimer disease (AD) is a progressive disorder that affects cognitive function. There is increasing support for the role of neuroinflammation and aberrant immune regulation in the pathophysiology of AD. The immunoregulatory human leukocyte antigen (HLA) complex has been linked to susceptibility for a number of neurodegenerative diseases, including AD; however, studies to date have failed to consistently identify a risk HLA haplotype for AD. Contributing to this difficulty are the complex genetic organization of the HLA region, differences in sequencing and allelic imputation methods, and diversity across ethnic populations.

Methods and findings

Building on prior work linking the HLA to AD, we used a robust imputation method on two separate case-control cohorts t

SUBMITTER: Steele NZ 

PROVIDER: S-EPMC5369701 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature