Expression of claudin-11, -23 in different gastric tissues and its relationship with the risk and prognosis of gastric cancer.

ABSTRACT: Claudins play an important role in regulating the permeability of epithelial and endothelial cells and in the maintenance of cell polarity. We aimed to investigate expression of claudin-11, -23 in different gastric tissues and its relationship with clinicopathologic parameters and prognosis of gastric cancer. We compared their expression levels in the paired cancerous tissues versus those in the adjacent noncancerous tissues by real-time PCR, western blotting and immunohistochemistry. The results showed that the expression of claudin-11, -23 was greatly increased in paracancerous gastric tissue compared with cancerous tissue. We also compared their expression levels of tissues from gastric cancer, superficial gastritis, and atrophic gastritis by immunohistochemistry. The results indicated

SUBMITTER: Lu Y 

PROVIDER: S-EPMC5369768 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature