Identification of novel biomarkers for prediction of neurological prognosis following cardiac arrest.

ABSTRACT:

Background

Early prognostication of neurological outcome in comatose patients after cardiac arrest (CA) is important for devising patient treatment strategies. However, there is still a lack of sensitive and specific biomarkers for easy identification of these patients. We evaluated whether molecular signatures from blood of CA patients might help to improve the prediction of neurological outcome.

Methods

We examined 22 comatose patients resuscitated after CA and obtained peripheral blood samples 48 hours after CA. To identify novel blood biomarkers, we aimed to measure neurological outcomes according to the Cerebral Performance Category (CPC) score at 6 months after CA and to determine blood transcriptome-based molecular signature of poor neurological outcome group.

Resu

SUBMITTER: Eun JW 

PROVIDER: S-EPMC5369953 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature