Glucose transporter GLUT1 expression and clinical outcome in solid tumors: a systematic review and meta-analysis.

ABSTRACT: Glucose transporter 1 (GLUT1), the uniporter protein encoded by the SLC2A1 gene, is a key rate-limiting factor in the transport of glucose in cancer cells, and frequently expressed in a significant proportion of human cancers. Numerous studies have reported paradoxical evidence of the relationship between GLUT1 expression and prognosis in solid human tumors. To address this discrepancy, we conducted a thorough search of Pubmed and Web of Science for studies evaluating the expression of GLUT1 and overall survival (OS) and disease-free survival (DFS) in patients with solid cancer from 1993 to April 2016. Data from published researches were extracted and computed into odds ratio (OR). A total of 26 studies including 2948 patients met our search criteria and were evaluated. Overexpression of G

SUBMITTER: Wang J 

PROVIDER: S-EPMC5370007 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature