LigB subunit vaccine confers sterile immunity against challenge in the hamster model of leptospirosis.

ABSTRACT: Neglected tropical diseases, including zoonoses such as leptospirosis, have a major impact on rural and poor urban communities, particularly in developing countries. This has led to major investment in antipoverty vaccines that focus on diseases that influence public health and thereby productivity. While the true, global, impact of leptospirosis is unknown due to the lack of adequate laboratory diagnosis, the WHO estimates that incidence has doubled over the last 15 years to over 1 million cases that require hospitalization every year. Leptospirosis is caused by pathogenic Leptospira spp. and is spread through direct contact with infected animals, their urine or contaminated water and soil. Inactivated leptospirosis vaccines, or bacterins, are approved in only a handful of countries due t

SUBMITTER: Conrad NL 

PROVIDER: S-EPMC5370146 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature