Gene-centric analysis implicates nuclear encoded mitochondrial protein gene variants in migraine susceptibility.

ABSTRACT:

Background

Migraine is a common neurological disorder which affects a large proportion of the population. The Norfolk Island population is a genetically isolated population and is an ideal discovery cohort for genetic variants involved in complex disease susceptibility given the reduced genetic and environmental heterogeneity. Given that the majority of proteins responsible for mitochondrial function are nuclear encoded, this study aimed to investigate the role of Nuclear Encoded Mitochondrial Protein (NEMP) genes in relation to migraine susceptibility.

Methods

A gene-centric association analysis of NEMP genes was undertaken in the most related individuals (n = 315) within the genetically isolated Norfolk Island population. The discovery phase included genes with thre

SUBMITTER: Stuart S 

PROVIDER: S-EPMC5370233 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature