Mobility of a Mononucleotide within a Lipid Matrix: A Neutron Scattering Study.

ABSTRACT: An essential question in studies on the origins of life is how nucleic acids were first synthesized and then incorporated into compartments about 4 billion years ago. A recent discovery is that guided polymerization within organizing matrices could promote a non-enzymatic condensation reaction allowing the formation of RNA-like polymers, followed by encapsulation in lipid membranes. Here, we used neutron scattering and deuterium labelling to investigate 5'-adenosine monophosphate (AMP) molecules captured in a multilamellar phospholipid matrix. The aim of the research was to determine and compare how mononucleotides are captured and differently organized within matrices and multilamellar phospholipid structures and to explore the role of water in organizing the system to determine at which

SUBMITTER: Misuraca L 

PROVIDER: S-EPMC5370402 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature