The History of Bordetella pertussis Genome Evolution Includes Structural Rearrangement.

ABSTRACT: Despite high pertussis vaccine coverage, reported cases of whooping cough (pertussis) have increased over the last decade in the United States and other developed countries. Although Bordetella pertussis is well known for its limited gene sequence variation, recent advances in long-read sequencing technology have begun to reveal genomic structural heterogeneity among otherwise indistinguishable isolates, even within geographically or temporally defined epidemics. We have compared rearrangements among complete genome assemblies from 257 B. pertussis isolates to examine the potential evolution of the chromosomal structure in a pathogen with minimal gene nucleotide sequence diversity. Discrete changes in gene order were identified that differentiated genomes from vaccine referen

SUBMITTER: Weigand MR 

PROVIDER: S-EPMC5370423 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature