Basal-like breast cancer: molecular profiles, clinical features and survival outcomes.

ABSTRACT:

Background

Basal-like constitutes an important molecular subtype of breast cancer characterised by an aggressive behaviour and a limited therapy response. The outcome of patients within this subtype is, however, divergent. Some individuals show an increased risk of dying in the first five years, and others a long-term survival of over ten years after the diagnosis. In this study, we aim at identifying markers associated with basal-like patients' survival and characterising subgroups with distinct disease outcome.

Methods

We explored the genomic and transcriptomic profiles of 351 basal-like samples from the METABRIC and ROCK data sets. Two selection methods, labelled Differential and Survival filters, were employed to determine genes/probes that are differentially expressed i

SUBMITTER: Milioli HH 

PROVIDER: S-EPMC5370447 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature