Association between Body Mass Index and Cancer Survival in a Pooled Analysis of 22 Clinical Trials.

ABSTRACT:

Background

Data are inconsistent on the association between body mass index (BMI) at time of cancer diagnosis and prognosis. We used data from 22 clinical treatment trials to examine the association between BMI and survival across multiple cancer types and stages.

Methods

Trials with ≥5 years of follow-up were selected. Patients with BMI < 18.5 kg/m² were excluded. Within a disease, analyses were limited to patients on similar treatment regimens. Variable cutpoint analysis identified a BMI cutpoint that maximized differences in survival. Multivariable Cox regression analyses compared survival between patients with BMI above versus below the cutpoint, adjusting for age, race, sex, and important disease-specific clinical prognostic factors.

Results

A total of

SUBMITTER: Greenlee H 

PROVIDER: S-EPMC5370550 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature