Epigenetic aging signatures in mice livers are slowed by dwarfism, calorie restriction and rapamycin treatment.

ABSTRACT:

Background

Global but predictable changes impact the DNA methylome as we age, acting as a type of molecular clock. This clock can be hastened by conditions that decrease lifespan, raising the question of whether it can also be slowed, for example, by conditions that increase lifespan. Mice are particularly appealing organisms for studies of mammalian aging; however, epigenetic clocks have thus far been formulated only in humans.

Results

We first examined whether mice and humans experience similar patterns of change in the methylome with age. We found moderate conservation of CpG sites for which methylation is altered with age, with both species showing an increase in methylome disorder during aging. Based on this analysis, we formulated an epigenetic-aging model in mice usin

SUBMITTER: Wang T 

PROVIDER: S-EPMC5371228 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature