Tissue and time specific expression pattern of interferon regulated genes in the chicken.

ABSTRACT:

Background

Type I interferons are major players against viral infections and mediate their function by the induction of Interferon regulated genes (IRGs). Recently, it became obvious that these cytokines have a multitude of additional functions. Due to the unique features of the chickens' immune system, available data from mouse models are not easily transferable; hence we performed an extensive analysis of chicken IRGs.

Results

A broad database search for homologues to described mammalian IRGs (common IRGs, cIRGs) was combined with a transcriptome analysis of spleen and lung at different time points after application of IFNα. To apply physiological amounts of IFN, half-life of IFN in the chicken was determined. Interestingly, the calculated 36 min are considerably shorter t

SUBMITTER: Roll S 

PROVIDER: S-EPMC5371264 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature