Factors associated with early mycological clearance in HIV-associated cryptococcal meningitis.

ABSTRACT:

Introduction

The first-line combination therapy for HIV-associated cryptococcal meningitis (CM), a condition of high mortality particularly in the first two weeks of treatment, consists of amphotericin B plus flucytosine (5-FC). Given that 5-FC remains unavailable in many countries, the knowledge of factors influencing mycological clearance in patients treated with second-line therapy could contribute to effective management.

Objectives

To determine the factors associated with the clearance of Cryptococcus sp. from the cerebrospinal fluid by the second week of effective antifungal therapy (early mycological clearance) in HIV-associated CM.

Methods

Retrospective cohort study based on secondary data corresponding to HIV-associated CM cases hospitalized at a tertiary hea

SUBMITTER: Concha-Velasco F 

PROVIDER: S-EPMC5371305 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature