Sequencing of bla_IMP-Carrying IncN2 Plasmids, and Comparative Genomics of IncN2 Plasmids Harboring Class 1 Integrons.

ABSTRACT: This work presents the complete nucleotide sequences of p0801-IMP from Klebsiella pneumoniae, p7121-IMP from K. oxytoca, and p17285-IMP from Citrobacter freundii, which are recovered from three different cases of nosocomial infection. These three plasmids represent the first fully sequenced bla_IMP-carrying IncN2 plasmids. Further comparative genomics analysis of all the five integron-carrying IncN2 plasmids p0801-IMP, p7121-IMP, p17285-IMP, pJIE137, and p34983-59.134kb indicates that they possess conserved IncN2 backbones with limited genetic variations with respect to gene content and organization. Four class 1 integrons (bla_IMP-1-carrying In1223 in p0801-IMP/p7121-IMP, bla_IMP-8-carrying In655 in p17285-IMP, In27 i

SUBMITTER: Jiang X 

PROVIDER: S-EPMC5371602 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature