Global Fecal and Plasma Metabolic Dynamics Related to Helicobacter pylori Eradication.

ABSTRACT: Background:Helicobacter pylori colonizes the gastric mucosa of more than half of the world's population. There is increasing evidence H. pylori protects against the development of obesity and childhood asthma/allergies in which the development of these diseases coincide with transient dysbiosis. However, the mechanism underlying the association of H. pylori eradication with human metabolic and immunological disorders is not well-established. In this study, we aimed to investigate the local and systemic effects of H. pylori eradication through untargeted fecal lipidomics and plasma metabolomics approaches by liquid chromatography mass spectrometry (LC-MS). Results: Our study revealed that eradication of H. pylori eradication (i.e., loss of

SUBMITTER: Yap TW 

PROVIDER: S-EPMC5371670 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature