Phosphatidylinositol (4,5)-bisphosphate dynamically regulates the K_2P background K⁺ channel TASK-2.

ABSTRACT: Two-pore domain K_2P K⁺ channels responsible for the background K⁺ conductance and the resting membrane potential, are also finely regulated by a variety of chemical, physical and physiological stimuli. Hormones and transmitters acting through Gq protein-coupled receptors (GqPCRs) modulate the activity of various K_2P channels but the signalling involved has remained elusive, in particular whether dynamic regulation by membrane PI(4,5)P₂, common among other classes of K⁺ channels, affects K_2P channels is controversial. Here we show that K_2P K⁺ channel TASK-2 requires PI(4,5)P₂ for activity, a dependence that accounts for its run down in the absence of intracellular ATP and its full r

SUBMITTER: Niemeyer MI 

PROVIDER: S-EPMC5371824 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature