PEGylated Artificial Antibodies: Plasmonic Biosensors with Improved Selectivity.

ABSTRACT: Molecular imprinting, which involves the formation of artificial recognition elements or cavities with complementary shape and chemical functionality to the target species, is a powerful method to overcome a number of limitations associated with natural antibodies. An important but often overlooked consideration in the design of artificial biorecognition elements based on molecular imprinting is the nonspecific binding of interfering species to noncavity regions of the imprinted polymer. Here, we demonstrate a universal method, namely, PEGylation of the noncavity regions of the imprinted polymer, to minimize the nonspecific binding and significantly enhance the selectivity of the molecular imprinted polymer for the target biomolecules. The nonspecific binding, as quantified by the localize

SUBMITTER: Luan J 

PROVIDER: S-EPMC5371828 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature