Trajectories of CKD-MBD biochemical parameters over a 2-year period following diagnosis of secondary hyperparathyroidism: a pharmacoepidemiological study.

ABSTRACT:

Objectives

To define groups of patients according to the changes of biochemical parameters, that is, serum calcium, phosphate and parathyroid hormone (PTH), over a 2-year follow-up period using group-based multi-trajectory modeling (GBMM) among a cohort of dialysis patients with newly diagnosed secondary hyperparathyroidism (SHPT) (ie, PTH≥500 ng/L for the first time) and to compare their patient characteristics and treatments.

Design

Pharmacoepidemiological study.

Setting

In the 12 dialysis units located in the French region of Lorraine.

Participants

A total of 269 dialysis patients with newly diagnosed SHPT were prospectively included from December 2009 to May 2012 and followed-up for 2 years.

Results

We identified four distinct trajectory groups: 'rap

SUBMITTER: Filipozzi P 

PROVIDER: S-EPMC5372074 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature