Relevance of secretor status genotype and microbiota composition in susceptibility to rotavirus and norovirus infections in humans.

ABSTRACT: Host genetic factors, such as histo-blood group antigens (HBGAs), are associated with susceptibility to norovirus (NoV) and rotavirus (RV) infections. Recent advances point to the gut microbiome as a key player necessary for a viral pathogen to cause infection. In vitro NoV attachment to host cells and resulting infections have been linked to interactions with certain bacterial types in the gut microbiota. We investigated the relationship between host genotype, gut microbiota, and viral infections. Saliva and fecal samples from 35 adult volunteers were analysed for secretor status genotype, the gut microbiota composition by 16S rRNA gene sequencing, and salivary IgA titers to NoV and RV. Higher levels of IgA against NoV and RV were related to secretor-positive status. No significant differ

SUBMITTER: Rodriguez-Diaz J 

PROVIDER: S-EPMC5372083 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature