Amelioration of experimental autoimmune encephalomyelitis by clozapine is not associated with defective CD4 T cell responses.

ABSTRACT: Atypical antipsychotic agents, such as clozapine, are used for treating psychosis and depression and have recently been found to modulate neuroinflammation. We have shown previously that treatment of mice with the atypical antipsychotic agents, clozapine or risperidone, attenuates disease severity in experimental autoimmune encephalomyelitis (EAE); however, the mechanism by which they are protective is unknown. In this study, we investigated the effects of clozapine on CD4⁺ T cell responses and found that clozapine did not significantly affect the expansion of myelin-specific T cells, their differentiation into pathogenic subsets, or their encephalitogenic capacity to induce EAE. Interestingly, although clozapine enhanced differentiation of regulatory T (Treg) cells, in vivo neu

SUBMITTER: Zareie P 

PROVIDER: S-EPMC5372297 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature