Evolutionary origin and function of NOX4-art, an arthropod specific NADPH oxidase.

ABSTRACT:

Background

NADPH oxidases (NOX) are ROS producing enzymes that perform essential roles in cell physiology, including cell signaling and antimicrobial defense. This gene family is present in most eukaryotes, suggesting a common ancestor. To date, only a limited number of phylogenetic studies of metazoan NOXes have been performed, with few arthropod genes. In arthropods, only NOX5 and DUOX genes have been found and a gene called NOXm was found in mosquitoes but its origin and function has not been examined. In this study, we analyzed the evolution of this gene family in arthropods. A thorough search of genomes and transcriptomes was performed enabling us to browse most branches of arthropod phylogeny.

Results

We have found that the subfamilies NOX5 and DUOX are present in all

SUBMITTER: Gandara ACP 

PROVIDER: S-EPMC5372347 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature