CXCR3⁺ monocytes/macrophages are required for establishment of pulmonary metastases.

ABSTRACT: We present a new foundational role for CXCR3⁺ monocytes/macrophages in the process of tumor engraftment in the lung. CXCR3 is associated with monocytic and lymphocytic infiltration of inflamed or tumor-bearing lung. Although the requirement for tumor-expressed CXCR3 in metastatic engraftment has been demonstrated, the role of monocyte-expressed CXCR3 had not been appreciated. In a murine model of metastatic-like melanoma, engraftment was coordinate with CXCR3⁺ monocyte/macrophage accumulation in the lungs and was sensitive to pharmacologic inhibition of CXCR3 signaling. Tumor engraftment to lung was impaired in CXCR3^-/- mice, and transient reconstitution with circulating CXCR3-replete monocytes was sufficient to restore engraftment. These data illustrate th

SUBMITTER: Butler KL 

PROVIDER: S-EPMC5372355 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature